"Breaking Down the Science: Illustrating the updates on the Cell-free DNA-derived methylome for Coronary artery disease"

#Sci_Comm, #Sci_Art, #Adobe_Illustrator

Recently, our research team at the Central Molecular Lab, GIPMER published a review article entitled, "An update on the cell-free DNA-derived methylome as a non-invasive biomarker for coronary artery disease". The highlights of this article were;

• Cardiac cell necrosis by atherosclerotic plaque rupture triggers myocardial infarction.

• Cell-free DNA released from the necrotized cells represents the tissue specificity.

• cfDNA is explored to comprehend the epigenomic landscape and CAD pathophysiology.

• The differential methylation pattern in CAD patients can be a potential biomarker(s) to detect CAD.

I was very fortunate to contribute in the drafting and visualization part of this manuscript. Here are the illustrations that I made using Adobe Illustrator that got published in this article;

Graphical abstract: Highlights the risk factors associated with CAD, methods to study and applications of the data derived from exploring the methylome from cfDNA of CAD patients.

Figure 1: Schematic representation of the homocysteine pathway in its normal homeostasis and the epigenetic changes leading to atherosclerosis. 

Figure 2: Technical approaches to study methylation with their advantages, and limitations. 

Reference: https://doi.org/10.1016/j.biocel.2024.106555