Unraveling the Impact of Mitochondrial Respiratory Complex I Genetic Aberrations on Neurological Disorders: A Visual Exploration

I am happy to share our recent review article entitled, "Genetic aberration analysis of mitochondrial respiratory complex I implications in the development of neurological disorders and their clinical significance". In addition to the conceptualization, drafting and reviewing, I contributed as an science illustrator too. Here are the the highlights and the artwork made using #Adobe_Illustrator that got published in the impactful and reputed journal of Ageing Research Reviews; Highlights:

• Comprehensive update on the mitochondrial complex-I associated neurological disorders.

• Mutational outlook of the rare neurological disorders with their clinical significance.

• Therapeutic advancements and clinical trials in the management of primary mitochondrial disorders.

Artwork:

Graphical abstract: An illustration of the involvement of mitochondrial Compex I in the neurological disorders highlighting the organs affected, current diagnostics and therapeutic approaches available.

Figure 1: An illustration of mitochondrial electron transport chain with six common Complex I associated neurological disorders viz. LS, LHON, MELAS, MERRF, PD and AD. Furthermore, it depictsthe disorder-associated prevalence, age-group affected, gender bias and major underlying genetic mutations.

Figure 2: A schematic representation of the Pronuclear transfer (PNT) method of Mitochondrial replacement therapy where the pathogenic mitochondria of the mother’s oocyte are replaced by the healthy mitochondria from a donor mother followed by the regular fertilization from the sperms of the biological father accordingly produces a baby termed as Three-parent baby.

Reference: https://doi.org/10.1016/j.arr.2023.101906